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Original Research (Original Article) 
JVS. 2020; 7(1): 86-96


Ultrasonic dispersion of aluminum hydroxide-adjuvanted Rift Valley Fever Vaccine enhances formula characteristics and immune response

Shourok Essam Aly, Karim Zaki, Soad ELsayed, Mahmoud Elgamal, Ausama A. Yousif and Mohamed A. Shalaby.

Abstract
Background: Rift Valley Fever (RVF) is a mosquito-borne viral zoonotic disease that is endemic in Africa and the Arabian Peninsula. Outbreaks of RVF resulted in severe losses to the animal industry and major threats to the public health. Control of RVF in Egypt is dependent on vector control and yearly vaccination of livestock using an aluminum hydroxide gel-adjuvanted inactivated Rift Valley fever virus (RVFV) vaccine.
Aim: Herein, we aimed to enhance the immunogenicity of the conventional vaccine by developing a smaller particle size vaccine formulation through ultrasonic dispersion of aluminum hydroxide adjuvant.
Methods: This was achieved by ultrasonication of aluminum hydroxide gel in the presence of trehalose as dispersant and measuring different physical characters including particle size, Zeta potential, loading capacity and imaging of adjuvant before and after formulation.
Results: Ultrasonication of aluminum hydroxide gel resulted in generation of 120-200 nm gel structures followed by vaccine formulation showed enhancement of vaccine loading capacity. Animals vaccinated using the enhanced formula were completely protected against RVF challenge virus and produced higher RVFV neutralizing antibody titers.
Conclusion: The vaccine developed based on small particle vaccine formulation is an economic solution that can be added inline to existing production platforms to enhance immunogenicity.

Key words: Dispersed, aluminum hydroxide adjuvant, RFV


 
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How to Cite this Article
Pubmed Style

SEA, KZ, ELsayed S, ME, . Ultrasonic dispersion of aluminum hydroxide-adjuvanted Rift Valley Fever Vaccine enhances formula characteristics and immune response. JVS. 2020; 7(1): 86-96.


Web Style

SEA, KZ, ELsayed S, ME, . Ultrasonic dispersion of aluminum hydroxide-adjuvanted Rift Valley Fever Vaccine enhances formula characteristics and immune response. http://www.j-virol-sci.com/?mno=81791 [Access: December 22, 2020].


AMA (American Medical Association) Style

SEA, KZ, ELsayed S, ME, . Ultrasonic dispersion of aluminum hydroxide-adjuvanted Rift Valley Fever Vaccine enhances formula characteristics and immune response. JVS. 2020; 7(1): 86-96.



Vancouver/ICMJE Style

SEA, KZ, ELsayed S, ME, . Ultrasonic dispersion of aluminum hydroxide-adjuvanted Rift Valley Fever Vaccine enhances formula characteristics and immune response. JVS. (2020), [cited December 22, 2020]; 7(1): 86-96.



Harvard Style

, S. E. A., , . K. Z., ELsayed, . S., , . M. E. & (2020) Ultrasonic dispersion of aluminum hydroxide-adjuvanted Rift Valley Fever Vaccine enhances formula characteristics and immune response. JVS, 7 (1), 86-96.



Turabian Style

, Shourok Essam Aly, Karim Zaki, Soad ELsayed, Mahmoud Elgamal, and Ausama A. Yousif and Mohamed A. Shalaby. 2020. Ultrasonic dispersion of aluminum hydroxide-adjuvanted Rift Valley Fever Vaccine enhances formula characteristics and immune response. Journal of Virological Sciences, 7 (1), 86-96.



Chicago Style

, Shourok Essam Aly, Karim Zaki, Soad ELsayed, Mahmoud Elgamal, and Ausama A. Yousif and Mohamed A. Shalaby. "Ultrasonic dispersion of aluminum hydroxide-adjuvanted Rift Valley Fever Vaccine enhances formula characteristics and immune response." Journal of Virological Sciences 7 (2020), 86-96.



MLA (The Modern Language Association) Style

, Shourok Essam Aly, Karim Zaki, Soad ELsayed, Mahmoud Elgamal, and Ausama A. Yousif and Mohamed A. Shalaby. "Ultrasonic dispersion of aluminum hydroxide-adjuvanted Rift Valley Fever Vaccine enhances formula characteristics and immune response." Journal of Virological Sciences 7.1 (2020), 86-96. Print.



APA (American Psychological Association) Style

, S. E. A., , . K. Z., ELsayed, . S., , . M. E. & (2020) Ultrasonic dispersion of aluminum hydroxide-adjuvanted Rift Valley Fever Vaccine enhances formula characteristics and immune response. Journal of Virological Sciences, 7 (1), 86-96.








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