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Original Article Open Access
JVS. 2017; 2(1): 32-41


Field application of trivalent foot and mouth disease vaccine adjuvanted with Zeolite.

Hiam Fakhry Alhawary, Assem Mohamed abobaker, Sonia Ahmed Rizk, Akram Zakria Hegazi, Abobaker Ahmed Agoor.

Abstract
Background: Zeolite is a mineral micro particle that in earlier studies has shown adjuvant activity against different antigens. Clinoptilolite zeolite is safe, economic and effective.
Objective: Comprehensive field sero-immunological study was conducted to reveal the adjuvant's effect of zeolite on the immune response of oil adjuvanted trivalent Foot and mouth disease (FMD) vaccine in cattle.
Methods: This study was conducted on 53 cattle in Kaliobia governrate - Egypt. Animals was vaccinated intramuscularly (I/M) with trivalent FMD zeolite (1 μg/dose) vaccine, serum samples were collected from vaccinated animals for 10 month . The humeral immune responses were monitored by Serum Neutralization Test (SNT) and ELIZA technique. The results revealed that vaccinated cattle reach the protective level at 2nd to 3rd week post vaccination (WPV) and continued up to 9th month post vaccination .
Results: Our results show that the incorporation of zeolite into FMDV vaccine induces an early & long period of high specific protective immune response in cattle.
Conclusion: Finally we recommended to use a ground zeolite alone as a potential and highly economic adjuvant in FMD vaccine for cattle.

Key words: FMD virus,vaccine zeolite ,SNT and ELISA .


 
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How to Cite this Article
Pubmed Style

Alhawary HF, abobaker AM, Rizk SA, Hegazi AZ, Agoor AA. Field application of trivalent foot and mouth disease vaccine adjuvanted with Zeolite.. JVS. 2017; 2(1): 32-41.



Web Style

Alhawary HF, abobaker AM, Rizk SA, Hegazi AZ, Agoor AA. Field application of trivalent foot and mouth disease vaccine adjuvanted with Zeolite.. www.scopemed.org/?mno=255627 [Access: October 17, 2017].



AMA (American Medical Association) Style

Alhawary HF, abobaker AM, Rizk SA, Hegazi AZ, Agoor AA. Field application of trivalent foot and mouth disease vaccine adjuvanted with Zeolite.. JVS. 2017; 2(1): 32-41.



Vancouver/ICMJE Style

Alhawary HF, abobaker AM, Rizk SA, Hegazi AZ, Agoor AA. Field application of trivalent foot and mouth disease vaccine adjuvanted with Zeolite.. JVS. (2017), [cited October 17, 2017]; 2(1): 32-41.



Harvard Style

Alhawary, H. F., abobaker, A. M., Rizk, S. A., Hegazi, A. Z. & Agoor, A. A. (2017) Field application of trivalent foot and mouth disease vaccine adjuvanted with Zeolite.. JVS, 2 (1), 32-41.



Turabian Style

Alhawary, Hiam Fakhry, Assem Mohamed abobaker, Sonia Ahmed Rizk, Akram Zakria Hegazi, and Abobaker Ahmed Agoor. 2017. Field application of trivalent foot and mouth disease vaccine adjuvanted with Zeolite.. Journal of Virological Sciences, 2 (1), 32-41.



Chicago Style

Alhawary, Hiam Fakhry, Assem Mohamed abobaker, Sonia Ahmed Rizk, Akram Zakria Hegazi, and Abobaker Ahmed Agoor. "Field application of trivalent foot and mouth disease vaccine adjuvanted with Zeolite.." Journal of Virological Sciences 2 (2017), 32-41.



MLA (The Modern Language Association) Style

Alhawary, Hiam Fakhry, Assem Mohamed abobaker, Sonia Ahmed Rizk, Akram Zakria Hegazi, and Abobaker Ahmed Agoor. "Field application of trivalent foot and mouth disease vaccine adjuvanted with Zeolite.." Journal of Virological Sciences 2.1 (2017), 32-41. Print.



APA (American Psychological Association) Style

Alhawary, H. F., abobaker, A. M., Rizk, S. A., Hegazi, A. Z. & Agoor, A. A. (2017) Field application of trivalent foot and mouth disease vaccine adjuvanted with Zeolite.. Journal of Virological Sciences, 2 (1), 32-41.



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