Field application of trivalent foot and mouth disease vaccine adjuvanted with Zeolite.

Hiam Fakhry Alhawary, Assem Mohamed abobaker, Sonia Ahmed Rizk, Akram Zakria Hegazi, Abobaker Ahmed Agoor

Abstract
Background: Zeolite is a mineral micro particle that in earlier studies has shown adjuvant activity against different antigens. Clinoptilolite zeolite is safe, economic and effective.
Objective: Comprehensive field sero-immunological study was conducted to reveal the adjuvant's effect of zeolite on the immune response of oil adjuvanted trivalent Foot and mouth disease (FMD) vaccine in cattle.
Methods: This study was conducted on 53 cattle in Kaliobia governrate - Egypt. Animals was vaccinated intramuscularly (I/M) with trivalent FMD zeolite (1 μg/dose) vaccine, serum samples were collected from vaccinated animals for 10 month . The humeral immune responses were monitored by Serum Neutralization Test (SNT) and ELIZA technique. The results revealed that vaccinated cattle reach the protective level at 2nd to 3rd week post vaccination (WPV) and continued up to 9th month post vaccination .
Results: Our results show that the incorporation of zeolite into FMDV vaccine induces an early & long period of high specific protective immune response in cattle.
Conclusion: Finally we recommended to use a ground zeolite alone as a potential and highly economic adjuvant in FMD vaccine for cattle.

Key words: FMD virus,vaccine zeolite ,SNT and ELISA .

ABOUT JOURNAL About Publisher Contact Us Editorial & Peer Review Process	POLICIES Privacy Policy Editorial Policy Author's Rights and Obligations Conflict of Interest Policy Plagiarism Policy Advertising Policy	STATEMENTS Terms of Use Author's Rights and Obligations Publication Ethics and Publication Malpractice Statement Protection of Research Participants (Statement On Human And Animal Rights) License Information

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access. The articles in Journal of Virological Sciences are open access articles licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

	Open Access and Peer-reviewed
Home Journal Issues Guide for Authors Editorial Board Aims & Scope About Journal News & Announcements

How to cite this article